| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new crosslinking composite biomaterial which exhibits excellent bioabsorbability and biocompatibility, is excellent in dissemination of cells and clinical handling property, has enough mechanical strength, is useful for regenerating or restructuring a covering material for skin wound such as skin ulcer and burn, or a skin tissue or living tissue or an internal organ such as ligament, bronchi and intestials, and provide an advantageous method for manufacturing the crosslinking composite biomaterial. SOLUTION: This biomaterial comprises a bioabsorbable synthetic polymer mesh body and a tissue-derived natural polymer porous body. The mesh body is made of a cloth, a woven fabric or an unwoven fabric, and a bioabsorbable synthetic polymer is formed from polylactic acid, polyglycolic acid or a copolymer of lactic acid with glycolic acid. The tissue-derived natural polymer is at least one kind selected from among collagen, gelatin, fibronectin or laminin. After treated in a tissue-derived natural polymer solution, the mesh body is freeze-dried, and the generated composite biomaterial is treated with a gaseous chemical crosslinking agent. |
