PARAMYXOVIRUS VECTOR FOR GENE TRANSFER TO THE CARDIOVASCULAR SYSTEM
摘要
The present invention provides a paramyxovirus vector for gene transfer to the cardiovascular system and uses thereof. The invention enables the efficient transfer of a foreign gene product to the cardiovascular system by use of the paramyxovirus vector. Products of genes introduced by intranasal or intramuscular administration of the paramyxovirus vector were detected in blood at high levels. The administration of a vector for the expression of the anti-inflammatory cytokine IL-10 inhibited collagen deposition in lung of pulmonary fibrosis model animal. Thus, the vector of the present invention is suitable for gene transfer to the cardiovascular system.
申请公布号
WO0238726(A2)
申请公布日期
2002.05.16
申请号
WO2001JP09786
申请日期
2001.11.08
申请人
DNAVEC RESEARCH INC.;GRIESENBACH, UTA;FERRARI, STEFANO;GEDDES, DUNCAN M.;ALTON, ERIC WFW;HASEGAWA, MAMORU;HOU, XIAOGANG
发明人
GRIESENBACH, UTA;FERRARI, STEFANO;GEDDES, DUNCAN M.;ALTON, ERIC WFW;HASEGAWA, MAMORU;HOU, XIAOGANG