| 发明名称 |
CRYSTALLINE (-)-3R,4R-TRANS-7-METHOXY-2,2- DIMETHYL-3-PHENYL-4-4-[2- (PYRROLIDIN-1- YL)ETHOXY]PHENYLCHROMAN HYDROFUMARATE, METHOD OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF DECREASE OR PROPHYLAXIS OF BONE RESORPTION |
| 摘要 |
organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to a novel crystalline (-)-3R, 4R-trans-7-methoxy-2,2-dimethyl-3- phenyl-4-4-[2-(pyrrolidin-1- yl)ethoxy] phenylchroman hydrofumarate, method of its synthesis, pharmaceutical composition based on thereof and method of decrease or prophylaxis of bone resorption including administration to patient the effective amount of indicated novel compound. Invention can be used in medicine as a therapeutic agent. EFFECT: new compound indicated above, valuable medicinal property. 9 cl, 1 tbl
|
| 申请公布号 |
RU2182149(C2) |
申请公布日期 |
2002.05.10 |
| 申请号 |
RU19980121844 |
申请日期 |
1997.05.07 |
| 申请人 |
NOVO NORDISK A/S |
发明人 |
TREPPENDAKHL' SVENN;ENSEN KLAUS SNAJ;MAKGRO SKOTT EH. |
| 分类号 |
A61K31/00;A61K31/40;A61K31/4025;A61P3/00;A61P19/00;A61P19/08;A61P19/10;C07D311/58;C07D405/12 |
主分类号 |
A61K31/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
