发明名称 |
CELLS EXPRESSING ZINC FINGER PROTEIN FOR DRUG DISCOVERY |
摘要 |
Disclosed herein are compositions and methods useful in screening a compound for its interaction and/or effect with a molecular target and/or cellular process. The invention is based on the construction of fusion proteins between a zinc finger protein designed to recognize a specific promoter and a transcription repressor or activator. Claimed are methods for the screening of substances capable of interacting with a specific cellular target or modulating a cellular pathway, involving cells stably transfected with, and expressing, the fusion protein.
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申请公布号 |
WO0159450(A3) |
申请公布日期 |
2002.05.02 |
申请号 |
WO2001US04301 |
申请日期 |
2001.02.08 |
申请人 |
SANGAMO BIOSCIENCES, INC.;CASE, CASEY |
发明人 |
CASE, CASEY |
分类号 |
C12N15/09;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12Q1/02;G01N33/15;G01N33/50;G01N33/58;G01N33/68;(IPC1-7):G01N33/50;C12N5/00;C12N15/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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