发明名称 |
COMBINATION OF FENOFIBRATE AND COENZYME Q10 FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION |
摘要 |
The present invention relates to a combination of a peroxisome proliferator activated receptor (PPAR) activator and a benzoquinone and their use in treating and/or preventing disorders characterized by endothelial dysfunction, such as cardiovascular disease, strokes and myocardial infarction. According to a preferred embodiment of the invention the benzoquinone or precursor thereof is a ubiquinone or precursor thereof, more preferably, coenzyme Q10 or a precursor thereof, and the PPAR activator is a fibrate or a thiazolidinedione, more preferably fenofibrate.
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申请公布号 |
CA2426625(A1) |
申请公布日期 |
2002.05.02 |
申请号 |
CA20012426625 |
申请日期 |
2001.10.23 |
申请人 |
FOURNIER LABORATORIES IRELAND LIMITED |
发明人 |
PLAYFORD, DAVID;WATTS, GERALD |
分类号 |
A61K47/20;A61K31/12;A61K31/122;A61K31/215;A61K31/216;A61K45/00;A61P3/06;A61P3/10;A61P7/08;A61P9/00;A61P9/04;A61P9/10;A61P9/12;A61P9/14;A61P39/06;A61P43/00;(IPC1-7):A61K31/215 |
主分类号 |
A61K47/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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