发明名称 |
Glucocorticoid receptor modulators |
摘要 |
The present invention provides non-steroidal compounds of Formula I, and prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e.g., agonists, partial agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides processes for preparing these compounds. <CHEM>
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申请公布号 |
EP1201649(A1) |
申请公布日期 |
2002.05.02 |
申请号 |
EP20010309064 |
申请日期 |
2001.10.25 |
申请人 |
PFIZER PRODUCTS INC. |
发明人 |
LIU, KEVIN KUN-CHIN;MORGAN, BRADLEY PAUL;ROBINSON, RALPH PELTON, JR. |
分类号 |
A61K31/439;C07D243/08;A61K31/27;A61K31/397;A61K31/40;A61K31/445;A61K31/4465;A61K31/46;A61K31/495;A61K31/4985;A61K31/4995;A61K31/55;A61K31/551;A61K45/00;A61P3/04;A61P3/10;A61P5/46;A61P25/22;A61P25/24;A61P25/28;A61P29/00;A61P43/00;C07C271/44;C07C271/52;C07D205/04;C07D207/08;C07D207/14;C07D211/14;C07D211/22;C07D211/56;C07D223/04;C07D295/08;C07D295/13;C07D295/20;C07D295/205;C07D451/02;C07D471/04;C07D487/08;(IPC1-7):C07C271/52;A61K31/325;C07D207/16;C07D295/12;A61K31/44 |
主分类号 |
A61K31/439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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