| 摘要 |
The invention relates to a composition for the topical treatment of a skin disease or of the affected tissue and to the treatment method. According to the invention, in order to achieve a hyaluronic acid concentration higher than 5 mg/cm2 on the skin or tissue, at a molecular weight lower than 750,000 Daltons, the composition comprises: 1...3% hyaluronic acid having a molecular weight lower than 750,000 Daltons or salts thereof, 1...5% non-steroid anti-inflammatory agent selected from among diclofenac sodium, indomethacin, naproxen, (+/-) tromethamine salt of ketorolac, ibuprofen, piroxicam, propionic acid derivatives, acetylsalicylic acid and flunixin and, optionally, 3...5% glycerine, 1...3% benzilic alcohol, 20% methoxypolyethyleneglycol and the up to 100% conditioning excipient which may be water, the percentage being expressed by weight. The treatment method consists in applying topically a composition wherein the hyaluronic acid and its salts represent 1...3%, having a molecular weight ranging between 150,000 and 750,000 Daltons, so that the hyaluronic acid form achieves a concentration higher than 5 mg/cm2 of skin or affected tissue, and which remains in the epidermis for a prolonged period of time, before passing through it.
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