| 摘要 |
The present invention provides compounds, their preparation and their use in therapy, particularly the treatment of bacterial infection, of the formula (I) wherein p is selected from 4, 5 and 6; q is selected from 3, 4 and 5; each T is the same or different and is selected from -X- and -CR<1 >2-; each R<1> may be the same or different and is selected from H, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 aryl and C4-18 aralkyl; each X may be the same or different and is selected from -CR<1 >2-, O, S, and NR' where each R' may be the same or different and is selected from H, C1-6 alkyl, C2-6 alkenyl, C2-12 alkynyl, C3-10 aryl, C4-12 aralkyl, C(O)R'', SO2R'' and C(O)NR''2 wherein R'' is selected from C1-6 alkyl, C2-6 alkenyl, C3-10 aryl, C4-12 aralkyl; A, B, Y<1>, Y<2>, Z<1>, Z<2>, Z<3> and Z<4> may be the same or different and are selected from H, halogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 aryl, C4-18 aralkyl, SR<2>, OR<3>, NR<4>R<5>, CO2R<6> and CONR<7 >2 wherein each R<2>, R<3> and R<4> is the same or different and is selected from H, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 aryl, C1-12 alkoyl, C3-12 aryloyl and C4-18 aralkyl, and each R<5>, R<6> and R<7> is the same or different and is selected from H, C1-12 alkyl, C2-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 aryl, C4-18 aralkyl; provided that at least one of A and B is OR<3>, and pharmaceutically acceptable derivatives thereof. |
