| 摘要 |
Described is a composition comprising a synergistic combination of a tyrosine kinase inhibitor and a chemical castration agent. The tyrosine kinase inhibitor is selected from a trkA inhibitor, a trkB inhibitor, a trkC inhibitor, or an indolocarbazole. Chemical castration agents include oestrogens; LHRH agonists, e.g., leuprolide acetate (LUPRON) and goserelin acetate (ZOLADEX); LHRH antagonists, e.g., ANTIDEs (Ares-Serono) and GANIRELIXe (Akzo Nobel); and antiandrogens, e.g., flutamide and nilutamide.
|
