发明名称 |
Pharmaceutical compositions containing antibody-enzyme conjugates in combination with prodrugs |
摘要 |
Prodrugs which can be activated by enzymes, are formulated for sequential administration, with enzyme conjugates. Either or each component comprises a polymeric carrier which allows it to be directed preferentially to the target tissue. A new polymer-prodrug conjugate is cleavable by cathepsin-B or othe invention is of particular utility for targeting solid tumours.
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申请公布号 |
US6372205(B1) |
申请公布日期 |
2002.04.16 |
申请号 |
US20000445732 |
申请日期 |
2000.05.22 |
申请人 |
THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON |
发明人 |
DUNCAN RUTH;SATCHI-FAINARO RONIT |
分类号 |
A61K45/00;A61K47/48;A61P35/00;(IPC1-7):A61K31/74 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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