发明名称 |
POLYMORPHISMS IN THE HUMAN HMG-COA REDUCTASE GENE |
摘要 |
This invention relates to polymorphisms in the human HMG-CoA reductase gene and corresponding novel allelic polypeptides encoded thereby. Particular polymorphisms are described in the promoter, exon 15 and introns 2, 5, 15 and 18. The invention also relates to methods and materials for analysing allelic variation in the HMG CoA reductase gene, and to the use of HMG-CoA reductase polymorphism in the diagnosis and treatment of HMG-CoA reductase mediated diseases such as dyslipidemia and other cardiovascular diseases such as myocardial infarction and stroke. |
申请公布号 |
EP1194595(A1) |
申请公布日期 |
2002.04.10 |
申请号 |
EP20000979230 |
申请日期 |
2000.06.19 |
申请人 |
ASTRAZENECA UK LIMITED |
发明人 |
MARCH, RUTH ELEANOR;THORNTON, SARAH MELISSA |
分类号 |
C12N15/09;A61K45/00;A61P3/06;A61P9/00;A61P9/10;A61P43/00;C12M1/00;C12N9/02;C12N9/04;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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