The present invention relates to compositions comprising a novel recombinant virus which replicates selectively in cells or tissues that are hypoxic or have an activated HIF pathway. The novel compositions of the invention comprise a recombinant virus genetically engineered to have an hypoxia-responsive element, or a multiplicity of such elements, operably linked to a promoter which is operably linked to a gene or genes which regulate or modulate replication of the virus or encode a therapeutic molecule. The invention also includes constructs useful for screening for agents which interact with proteins or genes in the hypoxia-inducible pathway.
申请公布号
WO0226192(A2)
申请公布日期
2002.04.04
申请号
WO2001US30236
申请日期
2001.09.26
申请人
EMORY UNIVERSITY;VAN MEIR, ERWIN;NICHOLSON, AINSLEY, C.;POST, DAWN, E.
发明人
VAN MEIR, ERWIN;NICHOLSON, AINSLEY, C.;POST, DAWN, E.