PHARMACEUTICAL COMPOSITION CONTAINING C-KIT-LIGAND AND HEMOPOIETIC FACTOR, METHOD OF ENHANCEMENT OF PERIPHERAL BLOOD STEM CELL LEVELS, ANTAGONIST OF C-KIT-LIGAND, ANTISENSE MOLECULE OF NUCLEIC ACID, METHOD OF ENHANCEMENT OF PERIPHERAL BLOOD CELL LEVELS EX-VIVO

摘要

medicine, pharmacy. SUBSTANCE: invention relates to a pharmaceutical composition containing c-kit-ligand and hemopoietic factor, method of enhancement of levels of stem cells in peripheral blood, antagonist of c-kit-ligand, antisense molecule of nucleic acid, method of enhancement of levels of stem cells in peripheral blood ex- vivo. Invention involves pharmaceutical composition based on c-kit-ligand that is a polypeptide encoded by nucleic acid SEQ ID NO:1 or natural hemopoietic variant of polypeptide and effective amount of hemopoietic factor, method of enhancement of levels of stem cells in peripheral blood using the indicated composition. Also, invention relates to antisense nucleic acids used as therapeutic agents and method of enhancement of levels of cells in peripheral blood ex-vivo including treatment of peripheral blood cells with indicated composition ex-vivo. EFFECT: development of novel hemopoietic agent. 14 cl, 35 dwg, 3 tbl, 3 ex