发明名称 |
Conversion of a watson-crick DNA to a hoogsteen-paired duplex |
摘要 |
A method is described for obtaining Hoogsteen-paired pyrimidine*purine duplexes, either by heating a triplex to dissociate a Watson-Crick paired pyrimidine strand or by linking two parallel strands at their 5' ends is disclosed. This duplex can be used as a new type of antisense molecule to pair with an RNA pyrimidine target sequence within an mRNA molecule. This duplex can also be used as a new type of antigene molecule to pair with a single-stranded DNA pyrimidine target sequence within the genome.
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申请公布号 |
US6362322(B1) |
申请公布日期 |
2002.03.26 |
申请号 |
US20000487130 |
申请日期 |
2000.01.19 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
GRAY DONALD M.;HASHEM GIHAN M. |
分类号 |
C12N15/09;A61K31/7088;A61K48/00;A61P3/10;A61P7/00;A61P7/06;A61P9/10;A61P27/02;A61P31/12;A61P31/18;A61P31/20;A61P31/22;A61P33/06;A61P35/00;C12N15/10;C12N15/113;C12Q1/68;(IPC1-7):C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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