T cell receptor transfer into a candidate effector cell or a precursor thereof

摘要

The present invention provides means and methods for generating effector cells that can be used for, for instance, adoptive immuno therapy. In one aspect is provided a method for providing a candidate effector cell with an antigen specific effector activity comprising providing said cell or a precursor thereof with a recombinant alpha beta T cell receptor specific for said antigen or a functional part, derivative and/or analogue of said receptor. In a preferred embodiment said effector cell comprises cytotoxic activity.