| 发明名称 |
Inhibitors of prenyl-protein transferase |
| 摘要 |
The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
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| 申请公布号 |
US6358985(B1) |
申请公布日期 |
2002.03.19 |
| 申请号 |
US19990342577 |
申请日期 |
1999.06.29 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
ANTHONY NEVILLE J.;BELL IAN M.;BESHORE DOUGLAS C.;CICCARONE TERRENCE M.;DE SOLMS S. JANE;DINSMORE CHRISTOPHER J.;STOKKER GERALD E. |
| 分类号 |
C07D498/08;A61K31/00;A61K31/337;A61K31/4174;A61K31/4188;A61P9/00;A61P9/10;A61P13/12;A61P27/02;A61P31/10;A61P31/12;A61P31/14;A61P35/00;A61P43/00;C07D515/08;(IPC1-7):A61K31/416;C07D487/08 |
主分类号 |
C07D498/08 |
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