| 摘要 |
<p>The invention relates to a method for the chemical preparation of labeled nucleosides via an oxidative-ring-opening step and a reductive-ring-closure step starting from a labeled D-glucose nucleoside resulting in the corresponding D-ribose-nucleoside by removing the carbon atom 3 on the glucose and comprising the steps of: 1. a protection of the sugar ring hydroxyl groups, 2. a sugar-base condensation, whereby the base is a purine or a pyrimidine, 3. a deprotection of the sugar ring hydroxyl groups, 4. an oxidative-ring-opening and removal of the carbon atom 3, and 5. a reductive-ring-closure resulting in labeled D-ribose-nucleoside. The invention further relates to a compound obtainable via the method according to the invention having the formula selected from Ä<13>C,<15>NÜ labeled 6'-O-mono- or 6'-O-bis-C1-C6-alkyloxytrityl-D-glycopyranosyl nucleosides, or Ä<13>C,<15>NÜ labeled tetra-O-acetyl-D-glycopyranosyl nucleosides or Ä<13>C,<15>NÜ labeled glycopyranosyl nucleosides.</p> |
