| 摘要 |
<p>Structural coordinates obtainable by subjecting a crystal comprising a dimethylarginine dimethylaminohydrolase (DDAH) or a fragment thereof or an arginine deliminase (DI) or a fragment thereof to X-ray diffraction measurements and deducing the structural coordinates from the diffraction measurements are used to identify, screen, characterise, design or modify a chemical entity. The chemical entities so generated may be used in methods of therapy or to identify the presence or absence of a DDAH or DI substrate.</p> |
