The invention relates to methods and systems of determining targets of compounds and compositions, as well as a high through-put method of screening antimicrobial agents. The methods involve (i) the prediction of a target using two and preferably at least three different submethods, (ii) identifying the gene encoding the target by each of these submethods, (iii) analysing the potential targets of each submethod to predict the putative target, and (iv) validating the target and the drug which perturbs it.
申请公布号
WO0216940(A2)
申请公布日期
2002.02.28
申请号
WO2001US26322
申请日期
2001.08.23
申请人
GENOME THERAPEUTICS CORPORATION
发明人
SULAVIK, MARK;LING, LOSEE, LUCY;OPPERMAN, TIM;MOIR, DONALD, T.;BUNKER, CHRISTOPHER