| 摘要 |
The invention relates to medicine, more specifically to pharmacology and can be used as new antibacterial and antimicrobial compositions which are particularly active against microbacteria. The essential of the invention lies in disclosing the powerful biological activity of thyazine derivatives of general formula (1), where, X=OH or O Y is chosen from a range NH-CN COOH -COOH, NH, O, I Ph Z=O (empty) or CH2-CH2 Four concrete compositions are studied: %-( alpha -carboxy ethylamine)- 4-2-phenyl-6H-1,3-thyazine-6-OH (i) 5-( pi -carboxyl phenil-4-hydroxy-2- phenyl-6H-1,3- thyazine-6- OH (II) 2-phenyl-7,8- dihydro -[1,3]-thiamine-[5,4-b] [1,4]-oxazine-4 (6H)- OH (III) 2-phenyl-7,8- dihydro -[1,4]-dioxin-[2,3-d]- thyazine-4-OH (IY) The examples of a synthesis of the compositions, results of a chemical and spectral analysis and a precise identification thereof are disclosed. Results of a practical appreciation of the biological activity ( activity against microbacteria, gramnegative and grampositive bacteria, against herpes virus) and also the data on the low toxicity of the compositions are also disclosed.
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