A process for the production of phospholipids by transphosphatidylation, which comprises the step of mixing a starting phospholipid with a receptor having one or more hydroxyl groups, phospholipase D and water in the absence of an organic solvent and homogenizing the resulting mixture and the step of subjecting the obtained homogeneous mixture to a reaction at 15 to 65 DEG C. The homogeneous mixture has a lamellar lyotropic liquid crystal structure and can give an objective phospholipid via transphosphatidylation without using an organic solvent or calcium.
