Imidazo-pyrazine derivatives as ligands for gaba receptors

摘要

A class of imidazo[1,2-alpha]pyrazine analogues substituted in the 3-position by a substituted phenyl ring, being selective ligands for GABA_A receptors which interact more favourably with the alpha2 and/or alpha3 subunit than with the alpha1 subunit, are accordingly of benefit in the treatment and/or prevention of a variety of disorders of the central nervous system, including anxiety and convulsions, with a reduced propensity to cause sedation.