ISOLATION OF DROSOPHILA AND HUMAN POLYNUCLEOTIDES ENCODING PAR-1 KINASE, POLYPEPTIDES ENCODED BY THE POLYNUCLEOTIDES AND METHODS UTILIZING THE POLYNUCLEOTIDES AND POLYPEPTIDES

摘要

Isolated nucleic acid molecules comprising polynucleotide having sequences that encode human and Drosophila PAR-1 kinases. Also provided are proteins a nd polypeptides encoded by the nucleic acid molecules, methods of modulating PA R- 1 expression and function, and methods of modulating the Wnt signaling pathw ay.