NON-HUMAN ANIMAL MODEL FOR GROWTH DEFICIENCY AND INFORMATION PROCESSING OR COGNITIVE FUNCTION DEFECTS AND USE THEREOF

摘要

The present invention provides a non-human animal model, particularly a mouse model, for growth deficiency and information procesing or cognitive function defects, in which modified growth hormone is expressed. The modified growth hormone and nucleic acids coding therefor are also provided, as are the correspondingly modified recombinant mouse and human growth hormones. The invention further provides uses for the non-human animal model and the modified growth hormones, in particular for the modified human growth hormone in treating medical conditions associated with over-expression of growth hormone or IGF-1.