发明名称 |
N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors. |
摘要 |
<p>The novel sulphonamidocarboxamides of the formula <IMAGE> in which X is a group of the formula X<1> or X<2>: <IMAGE> T is CH2 or O, and A, M, Q and Y have the meaning given in the description, and hydrates or solvates thereof inhibit the platelet aggregation and clotting of fibrinogen in the plasma induced by thrombin. They are prepared by amidination of a cyclic amino group representing the group X or by C(O)Q amide formation.</p> |
申请公布号 |
GR3036870(T3) |
申请公布日期 |
2002.01.31 |
申请号 |
GR20010401733T |
申请日期 |
2001.10.11 |
申请人 |
F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT |
发明人 |
ACKERMANN, JEAN;BANNER, DAVID;GUBERNATOR, KLAUS;HILPERT, KURT;SCHMID, GERARD |
分类号 |
A61K31/445;A61K;A61K31/155;A61K31/18;A61K31/33;A61K31/435;A61K31/4427;A61K31/452;A61K31/47;A61K31/535;A61K31/5375;A61K31/63;A61K31/675;A61K38/00;A61P7/02;C07C231/00;C07C237/16;C07C277/00;C07C279/16;C07C279/18;C07C279/20;C07C311/00;C07C311/19;C07D;C07D211/18;C07D211/26;C07D211/28;C07D211/36;C07D211/56;C07D265/06;C07D265/28;C07D265/30;C07D295/00;C07D401/12;C07D401/14;C07D413/12;C07F9/59;C07K5/06;C07K5/068;C07K5/072;C07K5/078;(IPC1-7):C07D211/26 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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