发明名称 |
CAPSAICIN RECEPTOR LIGANDS |
摘要 |
Disclosed are diaryl piperazines and related compounds. These compounds are selective modulators of capsaicin receptors, including human capsaicin receptors, that are, therefore, useful in the treatment of a chronic and acu te pain conditions, itch and urinary incontinence. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided . Compounds of the invention are also useful as probes for the localization of capsaicin receptors and as standards in assays for capsaicin receptor bindin g and capsaicin receptor mediated cation conductance. Methods of using the compounds in receptor localization studies are given.
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申请公布号 |
CA2415606(A1) |
申请公布日期 |
2002.01.31 |
申请号 |
CA20012415606 |
申请日期 |
2001.07.20 |
申请人 |
NEUROGEN CORPORATION |
发明人 |
BAKTHAVATCHALAM, RAJAGOPAL;HODGETTS, KEVIN J.;KRAUSE, JAMES E.;DESIMONE, ROBERT W.;HUTCHISON, ALAN;WHITE, GEOFFREY G. |
分类号 |
A61K31/496;A61K31/497;A61P11/08;A61P13/02;A61P17/02;A61P19/02;A61P25/02;A61P25/04;A61P25/06;A61P27/02;A61P29/00;A61P43/00;C07D213/74;C07D213/75;C07D217/22;C07D241/20;C07D295/194;C07D401/04;C07D401/14;C07D403/04;C07D405/12;C07D405/14;C07D407/14;C07D417/12;C07D417/14;(IPC1-7):C07D213/74;C07D295/192;C07D295/21;C07D295/215;A61K31/44;A61K31/440;A61K31/444;A61K31/472;A61K31/495 |
主分类号 |
A61K31/496 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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