摘要 |
An exsanguinous metabolic support system for maintaining an organ or tissue at a near normal metabolic rate is disclosed. The system employs an organ chamber comprising a container and a support member adapted to inhibit movement of the organ within the container during perfusion and/or transport. The organ chamber additionally comprises a conduit for receiving venous outflow of perfusion solution and preventing its contact with the outer surfaces of the organ. A conduit for receiving organ product enables the collection of organ product from a functional organ during perfusion. Use of the organ chamber supports de novo or continued synthesis of constituents necessary for long-term maintenance of organs for transplantation, for resuscitation and active repair of organs that have sustained warm ischemic damage, and for transportation of isolated organs is also disclosed.
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