| 摘要 |
Administration of certain beta -lactam compounds, has been found to provide significant neurotropic effects in warm-blooded vertebrates evidenced <i>inter alia</i> by anxiolytic and anti-aggressive behavior and enhanced cognition believed to be mediated by inhibition of neurogenic NAALADase and related neurogenic enzyme activity. The beta -lactamase inhibitor, clavulanic acid exhibits potent NAALADase inhibition, and it exhibits good blood brain barrier transport to provide effective inhibition of neurogenic NAALADase with significant neuro-therapeutic effects. Clavulanate acid and related compounds are useful, for example, for treatment of anxiety, anti-aggressive disorders, memory impairment, and disease states characterized by glutamate abnormalities. Therapeutic methods for using such compounds and their pharmaceutical formulations are described.
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