DISTINGUISHING MOLECULAR FORMS

摘要

A method for detecting aggregation or polymerization of molecules in a sampl e, which method comprises the steps of: a) exposing a sample containing the molecules to at least two labelling moieties which will bind to only a singl e mutually exclusive site on each of the said molecules; and b) determining whether multiply-bound labelling moieties are present. The method is particularly of use in differentiating pathogenic aggregated protein molecul es from non-pathogenic, non-aggregated protein molecules.