SPIRO BRIDGED AND UNBRIDGED HETEROCYCLIC COMPOUNDS

摘要

Compounds (I) and (II), including enantiomers, racemates and acid addition and quaternary salts, are for treating diseases of the central and peripheral nervous system, (see formula I and II) wherein in formula (I) Q is (CH2)m or C(CH3)2 attached to the 1',4' or 1',5' positions of the six-membered ring (m = 1, 2 or 3.) and in formula (II) Q is two hydrogen atoms, (CH2)m or C(CH3)2 (m = 1, 2 or 3) and n and p are each independently 0, 1, 2 or 3, provided that n + p = 2-3; R.degree. is hydrogen, methyl or OH; (see formula III) is (see formula IV), (see formula V), (see formula VI or VII) R and R' are independently H, NH2, NH-C1-6-alkyl, N(C1-6-alkyl)2, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-7- cycloalkyl, C1-6- alkyl substituted by 1-6 halogen atoms, HO- C1-6-alkyl, C1-6- alkoxy, C1-6-alkylthio, C1-6-alkoxy-C1-6-alkyl, carboxy-C1-6- alkyl, (C1-6-alkoxy)carbonyl-C1-6-alkyl, amino-C1-6-alkyl, mono- (C1-6-alkyl)amino-C1-6-alkyl, di-(C1-6-alkyl)amino-C1-6-alkyl, 2- oxo-pyrrolidin-1-yl-methyl, Ar, di(Ar)methylol, or (Ar)1-2C1-6 alkyl, or R' may be C1-6-alkanoyl or Arcarbonyl; and Ar denotes Ph optionally substituted by 1-3 of halogen, C1-6-alkyl, C1-6- alkoxy and GF3, subject to certain provisos.