GROWTH FACTOR COMPOSITIONS, PREPARATION AND USE

摘要

The invention in growth factor compositions includes: a novel compound which is a separate pure nicked or pure non- nicked species of epidermal growth factor EGF1-48 or its hEGF1-47 or hEGF1-4 9 congener compound, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition in dosage form comprising an effective amount of the novel compound; and use thereof for treating abnormal cell growth conditions including gastrointestinal/duodenal lesions; and methods of mak- ing the pure hEGF species. This unique therapeutic utility is enhanced by th e unexpected and heretofore unappreciated structural stability and resistance of the pure species to enzymatic degradation.