| 发明名称 |
TPL-2/COT KINASE AND METHODS OF USE |
| 摘要 |
It is shown that TPL-2 is responsible for phosphorylation of p105 and its resultant proteolysis, which leads to p50 Rel translocation to the nucleus. Accordingly, the invention provides TPL-2 as a specific regulator of the activation of NFkB, and thus as a modulator of inflammatory responses in which p105 is involved, as a target for the development of compounds capable of influencing NFkB activation. 68 claims, 14 figures
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| 申请公布号 |
BG105345(A) |
申请公布日期 |
2001.12.31 |
| 申请号 |
BG20010105345D |
申请日期 |
2001.03.15 |
| 申请人 |
BASF AKTIENGESELLSCHAFT;MEDICAL RESEARCH COUNCIL |
发明人 |
ALLEN, HAMISH J.;DIXON, RICHARD W.;KAMENS, JOANNE S.;WICKRAMASINGHE, DINELI;XU, YAJUN;BELICH, MONICA P.;JOHNSTON, LELAND H.;LEY, STEVEN C.;SALMERON, ANDRES |
| 分类号 |
C12N15/09;A61K31/00;A61K31/4439;A61K31/4706;A61K31/4745;A61K38/00;A61K39/395;A61K45/00;A61P1/00;A61P3/10;A61P5/48;A61P17/06;A61P29/00;C07K14/82;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/12;C12N15/54;C12Q1/02;G01N33/68;(IPC1-7):C12N15/54;A61K38/45;G01N33/50;A61K31/47;A61K31/44 |
主分类号 |
C12N15/09 |
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