发明名称 |
ARYL PHOSPHATE DERIVATIVES OF D4T HAVING ANTI-HIV ACTIVITY, MEDICAMENTS CONTAINING THE SAME AND THEIR USE |
摘要 |
Aryl phosphate derivatives of d4T with para-bromo substitution on the aryl group show markedly increased potency as anti-HIV agents without undesirable levels of cytotoxic activity. In particular, these derivatives are potent inhibitors of HIV reverse transcriptase. In a preferred aspect of the present invention, the phosphorus of the aryl phosphate group is further substituted with an amino acid residue that may be esterified or substituted, such as a methoxy alaninyl group. |
申请公布号 |
HU0102527(A2) |
申请公布日期 |
2001.12.28 |
申请号 |
HU20010002527 |
申请日期 |
1999.06.29 |
申请人 |
PARKER HUGHES INSTITUTE |
发明人 |
UCKUN FATIH M.;VIG RAKESH |
分类号 |
A61K31/7064;A61K31/7068;A61K31/7076;A61P31/18;C07H19/10;C07H19/20 |
主分类号 |
A61K31/7064 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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