发明名称 |
USE OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) INHIBITORS FOR REDUCING THE NUMBER OF POSTPRANDIAL TRIGLYCERIDE-RICH LIPOPROTEIN PARTICLES (PPTRL) |
摘要 |
The invention relates to the use of inhibitors of the microsomal triglycerid e transfer protein (MTP) for reducing the number of postprandial triglyceride- rich lipoprotein particles (ppTRL) or for reducing their decomposition products i.e. the cholesterol-rich "small remnant particle" (remnants). Said particles are associated with apolipoprotein B-48 (ApoB-48) and are designat ed as "ppTRL" in the further course of events.
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申请公布号 |
CA2413277(A1) |
申请公布日期 |
2001.12.27 |
申请号 |
CA20012413277 |
申请日期 |
2001.06.08 |
申请人 |
BAYER AKTIENGESELLSCHAFT |
发明人 |
MULLER, ULRICH;BISCHOFF, HILMAR;ZAISS, SIEGFRIED;GRUTZMANN, RUDI |
分类号 |
C07D275/06;A61K31/4035;A61K31/404;A61K31/4164;A61K31/4184;A61K31/427;A61K31/428;A61K31/437;A61K31/4439;A61K31/444;A61K31/5025;A61K31/519;A61K31/522;A61P3/00;A61P3/04;A61P3/06;A61P3/10;A61P5/50;A61P7/00;A61P9/00;A61P25/28;A61P43/00;C07D209/08;C07D209/48;C07D235/08;C07D235/18;C07D235/28;C07D401/04;C07D417/04;C07D471/04;C07D473/08;C07D487/04;(IPC1-7):A61K31/435 |
主分类号 |
C07D275/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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