| 发明名称 |
OSTEOLEVIN GENE POLYMORPHISMS |
| 摘要 |
The present inventon relates generally to genetic polymorphisms in the Van Buchem-sclerosteosis disease region. In particular, the present invention relates to genetic polymorphisms in the Van Buchem-sclerosteosis disease region that are associated with disorders resulting in either net excess bon e formation or insufficient bone formation in humans. Furthermore, isolated nucleic acid molecules encoding human osteolevin are provided. Osteolevin polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same.
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| 申请公布号 |
CA2412110(A1) |
申请公布日期 |
2001.12.27 |
| 申请号 |
CA20012412110 |
申请日期 |
2001.06.15 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG;UNIVERSITAIRE INSTELLING ANTWERPEN (U.I.A.) |
发明人 |
BALEMANS, WENDY;FOERNZLER, DOROTHEE;EBELING, MARTIN;PATEL, NEELA;VICKERY, BRIAN HENRY;VAN HUL, WIM |
| 分类号 |
C12N15/09;A61K38/00;A61K45/00;A61P19/08;C07K14/47;C07K14/51;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/12;C12P21/02;C12Q1/02;C12Q1/68;(IPC1-7):C12N15/12 |
主分类号 |
C12N15/09 |
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