ANTISENSE MOLECULES AND METHOD OF CONTROLLING EXPRESSION OF GENE FUNCTION BY USING THE SAME

摘要

Antisense molecules which act on both directions of the inhibition and restoration of the expression of a gene function and are capable of on/off switching appropriately depending on the external environment; and a method of reversibly controlling the expression of a gene function by using these antisense molecules. Such an antisense molecule, which has at least one sugar-base moiety consisting of a sugar and a purine or pyrimidine base bonded thereto via a glucoside bond, can bind to a gene and/or leave therefrom under the orientation control of the base moiety in the molecule by an orientation controlling factor.