Glycol and hydroxyphosphonate peptidomimetics as inhibitors of aspartyl proteases

摘要

Compounds of Formula Iare disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathepsin D. The compounds are therefore useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred compounds of Formula I, Y is an dialkoxyphosphonate, or alpha-hydroxyamide group and Z is an acyl or alpha-ketocarbamate functionality. Intermediates in the solid phase synthesis of compounds of Formula I, in which compounds are attached to a solid support, are also disclosed.