COMPOSITIONS WITH ANTI-PROLIFERATIVE ACTIVITIES AND METHODS FOR USE THEREOF

摘要

Peptides derived from a T cell clone which are useful in preventing or treating autoimmune disorders are provided including diabetes and transplant rejection. Also provided are method for inhibiting T cell proliferation and for treating or preventing autoimmune disorders via these peptides or active fragments or variants thereof or via molecular mimics of these peptides. In addition, methods for designing small molecule inhibitors of these peptides and uses for these inhibitors in treating or preventing immunodeficient disorders are provided.