Substituted tricyclics useful in sPLA2 induced diseases

摘要

A class of novel tricyclics is disclosed of the formula (I) <CHEM> wherein; A is phenil or pyridyl wherein the nitrogen is at the 5-, 6-, 7- or 8-position; one of B or D is nitrogen and the other is carbon; Z is cyclohexenyl, phenyl, pyridyl, wherein the nitrogen is at the 1-, 2-, or 3-position, or a 6-membered heterocyclic ring having one heteroatom selected from the group consisting of sulfur or oxygen at the 1-, 2-, 3-position, and nitrogen at the 1-, 2-, 3- or 4-position; <CHEM> is a double or single bond; together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.