发明名称 |
Prevention of insulin-dependent diabetes, complications thereof, or allograft rejection by inhibition of cyclooxygenase-2 activity |
摘要 |
Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease believed to be caused by an inflammatory process in the pancreas leading to selective destruction of the beta cells. Inducible cyclooxygenase (COX-2) is expressed under inflammatory conditions and its product prostaglandin E2 (PGE2) is an important inflammation mediator. Administration of the selective COX-2 inhibitor such as, e.g., NS-398 prevents the onset of diabetes in mice brought on by multiple low-doses of streptozotocin (STZ). Histological observations indicated that STZ-mediated destruction of beta cells was prevented by NS-398 treatment. Delayed (day 3) administration of NS-398 was also protective in this model. These results demonstrate the critical importance of COX-2 activity in autoimmune destruction of beta cells, and point to the fact that COX-2 inhibition should provide a preventive therapy against IDDM or other autoimmune problems, including allograft rejection. Inhibitors of NF-kappaB activation may also be used to prevent IDDM and allograft rejection. |
申请公布号 |
AU6140901(A) |
申请公布日期 |
2001.11.20 |
申请号 |
AU20010061409 |
申请日期 |
2001.05.10 |
申请人 |
OKLAHOMA MEDICAL RESEARCH FOUNDATION |
发明人 |
TAHEREH TABATABAIE;YASHIGE KOTAKE |
分类号 |
A61K31/00;A61K31/40;A61K31/63;A61P5/48 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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