| 摘要 |
<p>The present invention relates to a pharmaceutical composition containing itraconazole and its preparation, more particularly, to a pharmaceutical composition containing itraconazole obtained by dissolving, followed by spray-drying, and its preparation. The pharmaceutical composition containing itaconazole according to the present invention can increase the solubility of itaconazole and prevent the reduction of solubility of itraconazole caused as pH increases. As a result, the pharmaceutical composition of the present invention can improve the bioability of itraconazole and minimize absorption variance dependent on pH of the individual's stomach. Also, the pharmaceutical composition can be prepared by a single-process, i.e., a spray-spraying, such that it can be prepared in a economic manner.</p> |
