METHOD OF SCREENING COMPOUND HAVING ANTIMICROBIAL ACTIVITY ON PATHOGENIC MICROORGANISM INFECTING ORGANISM HAVING ACQUIRED IMMUNE MECHANISM BY USING ORGANISM HAVING NATURAL IMMUNE MECHANISM ALONE, AND METHOD OF EVALUATING THE ANTIMICROBIAL ACTIVITY BY USING ORGANISM HAVING NATURAL IMMUNE MECHANISM ALONE

摘要

It is examined whether or not silkworm larvae having a natural immune mechanism alone are useful as a system for evaluating an antimicrobial agent. It is found out that silkworm larvae die from infection by the injection of Micrococcus flavus or Pseudomonas aeruginosa. Effects of antimicrobial agents on silkworm larvae surprisingly agree with the clinical efficacies of these drugs on humans, i.e., an organism having an acquired immune mechanism.