| 摘要 |
PURPOSE: A process for producing 2,2,4,5-tetrasubstituted 3(2H)-furanone derivatives is provided, thereby the compounds, especially 4,5-diaryl-3(2H)-furanone derivatives can be produced in high yield. CONSTITUTION: The process for producing 2,2,4,5-tetrasubstituted 3(2H)-furanone derivatives of the formula(I) comprises of reacting the compound of formula(II) with 2-haloisobutyryl cyanide or 2-haloisobutyryl halide, if necessary, in the presence of an oxidizing agent, in which X is substituted or unsubstituted aryl or heteroaryl; Y is alkyl, cycloalkyl, substituted or unsubstituted aryl or heteroaryl; and the reaction is carried out in organic solvent in the presence of base, wherein base is sodium hydride, butyllithium, lithium t-butoxide, potassium t-butoxide, sodium t-butoxide, lithium diisopropyl amide, sodium bis(trimethylsillyl) amide, potassium bis(trimethylsillyl) amide, lithium bis(trimethylsillyl) amide or bromomagnesium diisopropyl amide.
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