BICYCLIC PIRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION

摘要

This invention provides cyclic heterocycles that are useful for treating cell proliferation disorders, such as cancer and restenosis, as well as an angiogenesis and atherosclerosis. They are potent inhibitors or cyclin-dependent kinases (cdks), growth factor-mediated kinases, and non-receptor kinases. The compounds are readily synthetized and can be administered by a variety of routes, including orally, and have sufficient bioavailability for clinical use. This invention provides compounds of formula where Z is N or CH; G is N or CH; W is NH, S, SO, or EO2, R1 includes phenyl and substituted phenyl, R2 includes alkyl and cycloalkyl, R3 includes alkyl and hydrogen, R8 and R9 include hydrogen and alkyl, and the pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical formulations comprising given compounds, together with a pharmaceutically acceptable carrier, diluent, or excipient therefor. 43 claims