发明名称 |
Transdermal administration of steroid drugs using hydroxide-releasing agents as permeation enhancers |
摘要 |
A method is provided for increasing the permeability of skin or mucosal tissue to transdermally administered steroid drugs. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the drug through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Formulations and drug delivery systems for co-administering a hydroxide-releasing agent with a steroid drug are provided as well. Optimally, the steroid drugs are a combination of an estrogen and progestin that may be administered in female hormone replacement therapy, to provide female contraception, and the like.
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申请公布号 |
US2001033870(A1) |
申请公布日期 |
2001.10.25 |
申请号 |
US20000737833 |
申请日期 |
2000.12.14 |
申请人 |
LUO ERIC C.;HSU TSUNG-MIN |
发明人 |
LUO ERIC C.;HSU TSUNG-MIN |
分类号 |
A61K9/00;A61K9/70;A61K31/137;A61K47/02;(IPC1-7):A61K33/08;A61K31/56 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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