ANIMAL AND CELL MODELS FOR TYPE II DIABETES AND THEIR USE
摘要
A transgenic diabetes type II model laboratory animal is disclosed which comprises beta -cells expressing a dominant negative form (dnFGFR1c) of FGFR1c. Also disclosed is the use of the <i>Ipf1/Pdx1</i> promoter for controlling expression of FGFR1c; beta -cells in wich the expression of PC1/3 is down-regulated or absent or which are competent to express a dominant negative form (dnFGFR1c) of FGFR1c; mature beta -cells incompetent to express Glut2 or in which the processing of proinsulin is substantially impaired; a method of preventing or treating type II diabetes.
