发明名称 |
Polypeptide of protein P140 and DNAs encoding it |
摘要 |
The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the polypeptide; vector derived with the DNA; host cells transformed with the vector; antibody of the polypeptide; pharmaceutical composition containing the peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the protein p140; agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylate protein p140, as active ingredient and the screening methods of the prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention not only improve the diabetes-derived hyperglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).
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申请公布号 |
US6303320(B1) |
申请公布日期 |
2001.10.16 |
申请号 |
US19980192435 |
申请日期 |
1998.01.08 |
申请人 |
ONO PHARMACEUTICAL CO., LTD. |
发明人 |
TAJIMA HISAO;KITAGAWA KOICHIRO;OHNO HIROYUKI |
分类号 |
A61K38/00;C07K14/47;C12N1/21;C12N15/12;C12P21/08;(IPC1-7):G01N33/53 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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