| 摘要 |
The invention provides a composition suitable for preparing a therapeutically-active biodegradable implant, comprising at least one crosslinkable multifunctional prepolymer having at least two polymerizable end groups and at least one biologically-active component, the said composition having a viscosity such that it is deformable at a temperature between 0 DEG C and 60 DEG C, more preferably between 15 DEG C and 40 DEG C into a three-dimensional shape and being hardenable by crosslinkage within the said temperature range. The invention further provides crosslinkable multifunctional prepolymers suitable for such a composition, comprising a biodegradable region made from a polyacetal and/or from an amorphous lactone-derived copolyester and/or comprising a hydrophilic region, as well as methods for producing such prepolymers. |
