TCL1 enhances Akt kinase activity and mediates its nuclear translocation

摘要

The TCL1 oncogene at 14q32.1 is involved in the development of human leukemia. This invention demonstrates the interaction between the Tcl1 and the Akt1 proteins. The physical interaction between endogenous Akt1 and Tcl1 occurs through the PH domain of the Akt1 protein. The present invention relates to the identification of Tcl1 mimics and Tcl1 antagonists that modifying this interaction, with the subsequent modification of apoptotic and proliferative signals.