发明名称 |
Process for producing camptothecin |
摘要 |
Problem: A large scale production of camptothecin, which is a starting compound of irinotecan hydrochloride and various camptothecin derivatives, at a low cost and with ease. Solution: A process for preparing camptothecin, characterized in that it comprises the following steps (a) and (b); (a) the step to hydrolyze 9-methoxycamptothecin or a natural material containing 9-methoxycamptothecin; (b) the step to convert 9-hydroxycamptothecin obtained in the step (a) into camptothecin by 9-O-perfluoro-lower-alkylsulfonylation or 9-O-phenyltetrazolylation, followed by hydrogenolysis. |
申请公布号 |
AU4273501(A) |
申请公布日期 |
2001.10.03 |
申请号 |
AU20010042735 |
申请日期 |
2001.03.21 |
申请人 |
KABUSHIKI KAISHA YAKULT HONSHA |
发明人 |
TAKASHI YAEGASHI;TAKANORI OGAWA;SEIGO SAWADA |
分类号 |
A61K31/475;A61P35/00;C07D491/22 |
主分类号 |
A61K31/475 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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